Synthetic Neurobiology Group

Ed Boyden, Ph.D., Principal Investigator

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Resources

Tools for mapping the molecular structure of the brain

  • Expansion microscopy: physical magnification with nanoscale precision

  • Pumby: programmable, modular RNA binding proteins

Tools for recording high-speed brain dynamics

  • SiRIs: spatial multiplexing of fluorescent reporters for imaging signaling network dynamics

  • SomaGCaMP: soma-targeted calcium indicators for precision neural population imaging

  • SomArchon: voltage indicator for population neural activity imaging

  • Archon1: well-localized, high-sensitivity, photostable fluorescent voltage indicator

  • Lightfield microscopy: fast 3-D neural imaging

  • Autopatching: robotic patch clamp in live brain

Optogenetics: molecules enabling neural control by light

  • ChromeQ: optogenetic activation with reduced proton and calcium currents

  • soCoChR: soma-targeted, high-amplitude channelrhodopsin

  • Jaws: red light-drivable halorhodopsin

  • Chrimson: red light-drivable channelrhodopsin

  • Chronos: high-speed, light-sensitive, channelrhodopsin

  • CoChR: large-current channelrhodopsin

  • Lumitoxins: light-actuated tethered toxin architecture

  • ArchT: light-sensitive archaerhodopsin

  • Arch: archaerhodopsin (light-driven proton pump)

  • Mac: light-driven proton pump of L. maculans

  • ChR2-2A-Halo: channelrhodopsin-halorhodopsin gene fusions

  • Halo/NpHR: halorhodopsin (light-driven chloride pump)

  • ChR2: channelrhodopsin-2 (light-driven cation channel)

  • Glial optogenetic tools

  • Accessory plasmids for optogenetics

  • Lentivirus production for high-titer, cell-specific, in vivo neural labeling

Optogenetics: hardware enabling neural control by light

  • Versatile, but Manually-Assembled, Optical Fiber/Laser System for In Vivo Optogenetics

  • Very Simple Off-The-Shelf Systems for In Vivo Optogenetics

Understanding normal and pathological brain computations

  • Closed-loop, ultraprecise, automated craniotomies

Home » Resources » Optogenetics: molecules enabling neural control by light

Optogenetics: molecules enabling neural control by light

ChromeQ: optogenetic activation with reduced proton and calcium currents

soCoChR: soma-targeted, high-amplitude channelrhodopsin

Jaws: red light-drivable halorhodopsin

Chrimson: red light-drivable channelrhodopsin

Chronos: high-speed, light-sensitive, channelrhodopsin

CoChR: large-current channelrhodopsin

Lumitoxins: light-actuated tethered toxin architecture

ArchT: light-sensitive archaerhodopsin

Arch: archaerhodopsin (light-driven proton pump)

Mac: light-driven proton pump of L. maculans

ChR2-2A-Halo: channelrhodopsin-halorhodopsin gene fusions

Halo/NpHR: halorhodopsin (light-driven chloride pump)

ChR2: channelrhodopsin-2 (light-driven cation channel)

Glial optogenetic tools

Accessory plasmids for optogenetics

Lentivirus production for high-titer, cell-specific, in vivo neural labeling

Copyright 2006-present, Ed Boyden | Accessibility